Effect of Polymorphism in the Drosophila Regulatory Gene Ultrabithorax on Homeotic Stability
Authors:
- 12 January 1996
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 271 (5246) , 200-203
Abstract
Development is buffered against unpredictable environmental and genetic effects. Here, a molecular genetic analysis of one type of developmental homeostasis, the establishment of thoracic segmental identity under the control of the Ultrabithorax ( Ubx ) gene in Drosophila melanogaster , is presented. Flies were artificially selected for differential sensitivity to the induction of bithorax phenocopies by ether vapor. The experiments demonstrated that increased sensitivity to ether correlated with a loss of expression of UBX in the third thoracic imaginal discs and that a significant proportion of the genetic variation for transcriptional stability can be attributed to polymorphism in the Ubx gene.Keywords
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