Determination of lovastatin acid in serum by gas chromatography/mass spectrometry
Authors:
- 1 May 1989
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 3 (5) , 132-134
Abstract
The acid form of lovastatin, an HMG‐CoA reductase inhibitor, was analyzed by gas chromatography/negativeion chemical ionization mass spectrometry after derivatization with pentafluorobenzyl bromide and bis‐(trimethylsilyl)trifluoroacetamide (BSTFA). Mass spectrometry of this derivative produced a dominant [M–181] − ion under chemical ionization conditions using ammonia as the reagent gas. The limit of detection was approximately 2 pg injected on column.Keywords
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