EFFECT OF A SYNTHETIC SULFATED POLYSACCHARIDE (SN‐263)* ON GASTRIC PEPTIC ACTIVITY IN HUMANS

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Summary: The effect of oral administration of a synthetic sulfated polysaccharide, amylopectin sulfate (SN‐263), on gastric peptic activity was studied in 49 patients with chronic duodenal ulcer. Five dose levels were studied: 100 mg, 200 mg, 300 mg, 500 mg, and 800 mg. A significant depression of gastric peptic activity was observed after oral administration of 200 and 300 mg of SN‐263. This inhibitory action appeared within 15 min and lasted for 45 min. At higher dose levels of 500 and 800 mg, a longer duration of inhibition lasting for 75 min was observed. Oral administration of 100 mg of SN‐263 was ineffective as an anti‐peptic agent. SN‐263 had no effect on the acidities of the gastric contents.When 200 mg of SN‐263 was given at two‐hour intervals, the inhibitory effect of the second administration of SN‐263 on gastric pepsin concentration was similar to that of the first dose. There was no evidence of a cumulative action. The addition of an anticholinergic drug, propanthelie bromide, which will inhibit acid and pepsin secretions at their source, further enhanced the action of SN‐263 as an antipeptic agent. Since SN‐263 exerts no antacid or anticholinergic action, its inhibitory effect on peptic activity must be a direct one.

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