Temperature Adaptation of Enzymes: Roles of the Free Energy, the Enthalpy, and the Entropy of Activation
Authors:
- 1 February 1973
- journal article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (2) , 430-432
Abstract
The enzymic reactions of ectothermic (cold-blooded) species differ from those of avian and mammalian species in terms of the magnitudes of the three thermodynamic activation parameters, the free energy of activation (Δ G ⧧ ), the enthalpy of activation (Δ H ⧧ ), and the entropy of activation (Δ S ⧧ ). Ectothermic enzymes are more efficient than the homologous enzymes of birds and mammals in reducing the Δ G ⧧ “energy barrier” to a chemical reaction. Moreover, the relative importance of the enthalpic and entropic contributions to Δ G ⧧ differs between these two broad classes of organisms.Keywords
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