The cell biology of autophagy in metazoans: a developing story
Open Access
- 15 July 2008
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 135 (14) , 2347-2360
Abstract
The cell biological phenomenon of autophagy (or `self-eating9) has attracted increasing attention in recent years. In this review, we first address the cell biological functions of autophagy, and then discuss recent insights into the role of autophagy in animal development, particularly in C. elegans, Drosophila and mouse. Work in these and other model systems has also provided evidence for the involvement of autophagy in disease processes, such as neurodegeneration, tumorigenesis, pathogenic infection and aging. Insights gained from investigating the functions of autophagy in normal development should increase our understanding of its roles in human disease and its potential as a target for therapeutic intervention.Keywords
This publication has 171 references indexed in Scilit:
- Autophagy in the Pathogenesis of DiseaseCell, 2008
- Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in DrosophilaCell, 2007
- Direct Induction of Autophagy by Atg1 Inhibits Cell Growth and Induces Apoptotic Cell DeathCurrent Biology, 2007
- Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesisCancer Cell, 2006
- Loss of autophagy in the central nervous system causes neurodegeneration in miceNature, 2006
- The role of autophagy during the early neonatal starvation periodNature, 2004
- Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat BodyDevelopmental Cell, 2004
- Influence of TOR kinase on lifespan in C. elegansNature, 2003
- Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional ConditionsDevelopmental Cell, 2002
- TGFβ-related pathwaysTrends in Genetics, 2000