Nanoscale Deformation and Nanomechanical Properties of Soft Matter Study Cases: Polydimethylsiloxane, Cells and Tissues
Open Access
- 18 July 2011
- journal article
- Published by Wiley in ISRN Nanotechnology
- Vol. 2011, 1-13
Abstract
Nanoindentation technique was used to investigate the nanomechanical behaviour of different soft materials. Polydimethylsiloxane (PDMS), cells and tissues were examined. The nanomechanical properties (with loading rate and creep study), namely, the hardness () and the elastic modulus () of PDMS, were determined. A classical Hertzian contact analysis was also performed in order to obtain values of . Moreover, the plastic deformation where no load had yet been applied to PDMS was investigated (zero load plastic deformation). Finally, the difficulties of measuring the nanomechanical properties (&) of cells and tissues were evaluated, showing the need for a modification of the current experimental protocols for preparing and mechanically testing in a mode that maintains their structure and their biological functioning in order to make indentation results more reproducible. Additionally, finite element method is used in order to simulate the nanoindentation of PDMS in correlation with experimental data.Keywords
This publication has 92 references indexed in Scilit:
- The mechanical properties of a surface-modified layer on polydimethylsiloxaneJournal of Materials Research, 2008
- Elastic clues in cancer detectionNature Nanotechnology, 2007
- Nanomechanical analysis of cells from cancer patientsNature Nanotechnology, 2007
- Biomechanics and biophysics of cancer cells☆Acta Materialia, 2007
- Accurately evaluating Young’s modulus of polymers through nanoindentations: A phenomenological correction factor to the Oliver and Pharr procedureApplied Physics Letters, 2006
- Nanoindentation of polydimethylsiloxane elastomers: Effect of crosslinking, work of adhesion, and fluid environment on elastic modulusJournal of Materials Research, 2005
- Optical Deformability as an Inherent Cell Marker for Testing Malignant Transformation and Metastatic CompetenceBiophysical Journal, 2005
- Tracking the hydrophobicity recovery of PDMS compounds using the adhesive force determined by AFM force distance measurementsPolymer, 2005
- Review of instrumented indentationJournal of Research of the National Institute of Standards and Technology, 2003
- Drug-Induced Changes of Cytoskeletal Structure and Mechanics in Fibroblasts: An Atomic Force Microscopy StudyBiophysical Journal, 2000