A clinical trial of multiple peptides vaccination for advanced head and neck cancer patients induced immune responses and prolonged OS
Authors:
- Yoshihiro YoshitakeYYYoshihiro Yoshitake
- Yasuharu NishimuraYNYasuharu Nishimura
- Yusuke NakamuraYNYusuke Nakamura
- Masanori ShinoharaMSMasanori Shinohara
- 2 April 2015
- journal article
- Published by Taylor & Francis in OncoImmunology
- Vol. 4 (8) , e1022307
Abstract
A phase II clinical trial for head and neck squamous cell cancer (HNSCC) patients using multiple peptides vaccine derived from tumor-associated antigens (TAAs) was performed. The therapy was well tolerated and overall survival was statistically significantly longer in vaccinated patients, and the patients exhibiting cytotoxic T lymphocytes (CTL) responses to multiple peptides exhibited better prognosis.Keywords
This publication has 10 references indexed in Scilit:
- Phase II Clinical Trial of Multiple Peptide Vaccination for Advanced Head and Neck Cancer Patients Revealed Induction of Immune Responses and Improved OSClinical Cancer Research, 2015
- Identification of immunogenic LY6K long peptide encompassing both CD4+and CD8+T-cell epitopes and eliciting CD4+T-cell immunity in patients with malignant diseaseOncoImmunology, 2014
- Identification of CDCA1‐derived long peptides bearing both CD4+ and CD8+ T‐cell epitopes: CDCA1‐specific CD4+ T‐cell immunity in cancer patientsInternational Journal of Cancer, 2013
- Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigensJournal of Translational Medicine, 2012
- Vaccination with multiple peptides derived from novel cancer‐testis antigens can induce specific T‐cell responses and clinical responses in advanced esophageal cancerCancer Science, 2009
- Cancer-Testis Antigen Lymphocyte Antigen 6 Complex Locus K Is a Serologic Biomarker and a Therapeutic Target for Lung and Esophageal CarcinomasCancer Research, 2007
- Identification of human leukocyte antigen‐A24‐restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapyCancer Science, 2007
- Concurrent Chemoradiotherapy for Locally Advanced, Nonmetastatic, Squamous Carcinoma of the Head and Neck: Consensus, Controversy, and ConundrumJournal of Clinical Oncology, 2006
- Genome-wide gene expression profile analysis of esophageal squamous cell carcinomasInternational Journal of Oncology, 2006
- Immunologic Monitoring of Cancer Vaccine Therapy: Results of a Workshop Sponsored by the Society for Biological TherapyJournal of Immunotherapy, 2002