Discovery of 3-peptide substituted arenobufagin derivatives as potent antitumor agents with low cardiotoxicity
Abstract
No abstract availableKeywords
Funding Information
- National Natural Science Foundation of China
This publication has 16 references indexed in Scilit:
- Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae)Toxicon, 2016
- The effects of bufadienolides on HER2 overexpressing breast cancer cellsTumor Biology, 2015
- Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathwayOncotarget, 2015
- Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinomaOncotarget, 2015
- A bufadienolide-loaded submicron emulsion for oral administration: Stability, antitumor efficacy and toxicityInternational Journal of Pharmaceutics, 2015
- A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I InhibitorsJournal of Medicinal Chemistry, 2013
- Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathwayCarcinogenesis, 2013
- Bufadienolides and their antitumor activityNatural Product Reports, 2011
- Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans CantorInternational Immunopharmacology, 2011
- Analyses of Biologically Active Steroids: Antitumor Active OSW-1 and Cardiotonic Marinobufotoxin, by Matrix-Assisted Laser Desorption/Ionization Quadrupole Ion Trap Time-of-Flight Tandem Mass SpectrometryChemical and Pharmaceutical Bulletin, 2009