Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins.
Authors:
- Ignazio CastagliuoloICIgnazio Castagliuolo
- Dirk HeitzmannDHDirk Heitzmann
- Richard WarthRWRichard Warth
- Shirin KordastiSKShirin Kordasti
- Maria SapnaraMSMaria Sapnara
- Evan A. ThomasETEvan A. Thomas
- Erik LindstromELErik Lindstrom
- Mikael ForsmanMFMikael Forsman
- Joel C. BornsteinJBJoel C. Bornstein
- Henrik SjövallHSHenrik Sjövall
- 1 April 1998
- journal article
- research article
- Published by American Physiological Society in Physiology
- Vol. 13 (2) , 58-63
Abstract
Experiments in intact animals exposed to enterotoxins demonstrate that neurons and immune cells of the lamina propria regulate toxin-induced diarrhea and tissue damage. Clostridium difficile toxins cause profound diarrhea and acute inflammation by activating a complex cascade initiated by toxin binding to enterocyte receptors.Keywords
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