Structure-activity relationship profiling of N-substituted 8-trifluoromethyl-9H-purin-6-amines as mitochondrial protonophores
Authors:
- 18 February 2026
- journal article
- Published by Elsevier in European Journal of Medicinal Chemistry
- Vol. 308, 118694
Abstract
No abstract availableKeywords
Funding Information
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK128612)
This publication has 41 references indexed in Scilit:
- Design, synthesis, and biological evaluation of imidazo[4,5-b]pyridine mitochondrial uncouplers for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)European Journal of Medicinal Chemistry, 2024
- Structural investigations on the mitochondrial uncouplers niclosamide and FCCPFEBS Open Bio, 2024
- UCP1 activation: Hottest target in the thermogenesis pathway to treat obesity using molecules of synthetic and natural originDrug Discovery Today, 2023
- Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplersBioorganic & Medicinal Chemistry Letters, 2022
- Oxidative stress in metabolic diseases: current scenario and therapeutic relevanceMolecular and Cellular Biochemistry, 2022
- Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorderBiomedicine & Pharmacotherapy, 2022
- Mitochondrial targeted strategies and their application for cancer and other diseases treatmentJournal of Pharmaceutical Investigation, 2020
- Chemiosmotic coupling in oxidative and photosynthetic phosphorylationBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2011
- 2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of DeathJournal of Medical Toxicology, 2011
- Mitochondria, Oxidants, and AgingCell, 2005