Comparison of Incidence of Invasive Streptococcus pneumoniae Disease Among Children Before and After Introduction of Conjugated Pneumococcal Vaccine

Authors:
  • KPKelvin Perry
    Kelvin Perry
  • CCChris E. Chacko
    Chris E. Chacko
  • WHWilliam B. Helton
    William B. Helton
  • MBMark G. Bowling
    Mark G. Bowling
  • SLStephen W. Looney
    Stephen W. Looney
  • GBGeorge E. Buck
    George E. Buck
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Abstract
The objective was to determine whether there has been a significant decrease in the incidence of invasive Streptococcus pneumoniae disease in the Louisville, KY, area since heptavalent pneumococcal conjugate vaccine was introduced in the winter of 1999–2000. A secondary objective was to collect demographic data regarding invasive S. pneumoniae disease in the Louisville, KY, area during the 1997–2002 period. Data on cases of invasive S. pneumoniae disease (defined by a positive culture for S. pneumoniae from the blood, pleural fluid or cerebrospinal fluid) were collected from the microbiology laboratories and medical records departments of all hospitals that treat children in the Louisville area, for 1997–2002. Trends in case rates for all cases of invasive S. pneumoniae disease from 1999 to 2002 were observed, and demographic and other factors regarding this illness were recorded for each patient. The trend for rates of invasive pneumococcal disease showed a significant decrease during the study period for all ages combined (P P Case rates for invasive S. pneumoniae disease among children decreased significantly in the 2-year period after introduction of the heptavalent S. pneumonia protein conjugate vaccine into this community.

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