Cell Proliferation Kinetics in the Gastrointestinal Tract of Man. III. Cell Renewal in Esophagus, Stomach, and Jejunum of a Patient With Treated Pernicious Anemia2

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Abstract
After administration of tritium-labeled thymidine, the replication of cells in the esophagus, stomach, and jejunum was studied in a patient with treated pernicious anemia. The gastric mucosa showed atrophy, and intestinal cell types were present in some areas. In adjacent mucosa, gastric polyps and carcinoma had previously been excised. The findings were compared with similar measurements made in a single patient with normal gastric mucosa. Epithelial cells of gastric mucosa in pernicious anemia demonstrated rapid proliferation and migration, comparable to, or slightly more rapid than, the normal mucosa, and, in addition, early extrusion into the gastric lumen. Grain counts over labeled mitoses in normal stomach were compatible with an interpretation of a uniform rate of DNA synthesis during most of the DNA synthesis phase. The distribution of DNA synthesizing cells in crypts of jejunum followed a statistical Poisson distribution. Estimates were also made of the rate of cell proliferation in the esophagus.

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