What Are the Major Physicochemical Factors in Determining the Preferential Nuclear Uptake of the DNA “Light-Switching” Ru(II)-Polypyridyl Complex in Live Cells via Ion-Pairing with Chlorophenolate Counter-Anions?

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Abstract
Delivering potential theranostic metal complexes into preferential cellular targets is becoming of increasing interest. Here we report that nuclear uptake of a cell-impermeable DNA “light-switching” Ru(II)-polypyridyl complex can be significantly facilitated by chlorophenolate counter-anions, which was found, unexpectedly, to be correlated positively with the binding stability but inversely with the lipophilicity of the formed ion pairs.
Funding Information
  • National Institute of Environmental Health Sciences (ES11497, ES00210)
  • National Center for Research Resources (RR01008)
  • National Natural Science Foundation of China (21621064, 21577149, 21836005, 21777180, 21407163, 21477139)
  • Chinese Academy of Sciences (XDB01020300)

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