MESOCORTICAL DOPAMINE NEURONS - RAPID TRANSMITTER TURNOVER COMPARED TO OTHER BRAIN CATECHOLAMINE SYSTEMS
Authors:
- MJ BANNONMBMJ BANNON
- EB BUNNEYEBEB BUNNEY
- RH ROTHRRRH ROTH
- 1 January 1981
- journal article
- research article
- Vol. 218 (1-2) , 376-382
Abstract
The decline of dopamine and norepinephrine after i.v. D,L-.alpha.-methyltyrosine methyl ester hydrochloride was used to determine the rate constants for catecholamine turnover in the [Sprague-Dawley] rat prefrontal cortex, olfactory tubercle and striatum. Dopamine turnover varied more between brain regions and was generally faster than the corresponding norepinephrine turnover. Prefrontal cortical dopamine was unaffected by dorsal noradrenergic bundle lesions. The turnover of prefrontal cortical dopamine was 2-4 .times. faster than dopamine turnover in the olfactory tubercle and striatum.Keywords
This publication has 4 references indexed in Scilit:
- Tolerance to fluphenazine and supersensitivity to apomorphine in central dopaminergic systems after chronic fluphenazine decanoate treatmentNaunyn-Schmiedeberg's Archives of Pharmacology, 1980
- Origin of dopaminergic innervation of the rat hippocampal formationNeuroscience Letters, 1980
- Action of the palmitic ester of pipotiazine on dopamine metabolism in the nigro-striatal, meso-limbic and meso-cortical systemsNaunyn-Schmiedeberg's Archives of Pharmacology, 1977
- Dopaminergic Neurons: Effects of Electrical Stimulation on Dopamine BiosynthesisMolecular Pharmacology, 1976