Opposite effects of anthelmintic treatment on microbial infection at individual versus population scales

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Abstract
Co-infection complicates treatment: Infections rarely occur in isolation, and treating one pathogen may have unpredictable effects on another. Ezenwa and Jolles, working on wild African buffaloes, expected that because deworming relieves immune suppression, such treatment would lead to a drop in tuberculosis because the animals would clear the second infection without further intervention. Not so. Deworming did improve the lot of parasite-infested individuals, but it also increased the spread of tuberculosis among the population. What apparently happened is that the worm-free buffalo lived longer but stayed infected with tuberculosis and had longer to spread the infection among the herd. Science , this issue p. 175
Funding Information
  • National Science Foundation Ecology of Infectious Diseases (EF-0723918/DEB-1102493, EF-0723928)

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