SP429ANTIOXIDANT AGENTS FOR DIABETIC KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

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Abstract
INTRODUCTION AND AIMS: Oxidative stress is a key player in the pathogenesis of renal damage associated with diabetes mellitus. In last years, evidence has accrued indicating that chronic administration of antioxidant supplements may somewhat ameliorate diabetic kidney disease (DKD). We theferore aimed at performing a systematic review and meta-analysis of randomized controlled trials (RCTs) in order to assess the effective usefulness of these agents for retarding DKD progression.