Synthesis of 2-[(Benzyloxycarbonylamino)phenylmethyl]-1,3,2-benzodioxaphosphole 2-Oxides

Authors:
  • QDQing Dai
    Qing Dai
  • RCRuyu Chen
    Ruyu Chen
  • CZChunxiang Zhang
    Chunxiang Zhang
  • ZLZhun Liu
    Zhun Liu
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Abstract
A simple method for the preparation of 2-[(benzyloxycarbonylamino)phenylmethyl]-1,3,2-benzodioxaphosphole 2-oxides in high yield consists of the three-component reaction of benzyl carbamate, an aromatic aldehyde and 2-chloro-1,3,2-benzodioxaphosphole in acetyl chloride or anhydrous benzene. Different reaction conditions have been investigated and the reaction mechanisms are suggested.