Nuclear Factor-κB: Fine-Tuning a Central Integrator of Diverse Biologic Stimuli
Open Access
- 1 January 2008
- journal article
- review article
- Published by Taylor & Francis in International Reviews of Immunology
- Vol. 27 (5) , 286-292
Abstract
The nuclear factor (NF)-κ B family of proteins is a key regulator of inflammation, innate immunity, and cell survival and differentiation. Components of these pathways are potential targets of intervention for inflammation, infectious diseases, and cancer. However, therapeutic interventions that dampen the host response to infection and injury must also recognize the autoregulatory loops in the “resolution” phase of inflammation and infection. A more precise fine-tuning of these pathways leading to NF-κB activation will require dissecting temporally the different phases of activation and endogenous autoregulatory deactivation programs in diseases and redefining end-points after drug/inhibitor treatment to correlate changes in these stages.Keywords
This publication has 21 references indexed in Scilit:
- Circuitry of nuclear factor κB signalingImmunological Reviews, 2006
- How Toll-like receptors signal: what we know and what we don’t knowCurrent Opinion in Immunology, 2006
- Signaling to NF-κBGenes & Development, 2004
- Inferences, questions and possibilities in Toll-like receptor signallingNature, 2004
- Genetic analysis of NF‐κB/Rel transcription factors defines functional specificitiesThe EMBO Journal, 2003
- The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene ActivationScience, 2002
- Phosphorylation Meets Ubiquitination: The Control of NF-κB ActivityAnnual Review of Immunology, 2000
- NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune ResponsesAnnual Review of Immunology, 1998
- THE NF-κB AND IκB PROTEINS: New Discoveries and InsightsAnnual Review of Immunology, 1996
- Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†Molecular and Cellular Biology, 1996