Serum levels of insulin‐like growth factor 1 in subjects with osteoarthritis of the knee. Data from the baltimore longitudinal study of aging

Authors:
  • MLMargaret Lethbridge‐Cejku
    Margaret Lethbridge‐Cejku
  • WSWilliam W. Scott
    William W. Scott
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Abstract
Objective. To examine the relationship between serum levels of insulin‐like growth factor 1 (IGF‐1) and osteoarthritis (OA) of the knee.Methods. Serum IGF‐1 levels were compared in 162 male and 101 female subjects age ≥20 stratified by presence of radiographic changes of OA of the knee.Results. Mean serum IGF‐1 levels were significantly lower in subjects with knee OA; however, after adjustment for age‐related changes in IGF‐1 levels, these differences were no longer significant.Conclusion. These data fail to support the hypothesis that serum IGF‐1 levels are reduced in subjects with OA of the knee independent of the known age‐related changes in these levels.

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