Synthesis and Anti-Herpes Virus Activity of 2‘-Deoxy-4‘-thiopyrimidine Nucleosides
Authors:
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 39 (3) , 789-795
Abstract
A series of 5-substituted 2‘-deoxy-4‘-thiopyrimidine nucleosides was synthesized and evaluated as potential antiviral agents. A number of analogues such as 2‘-deoxy-5-propyl-4‘-thiouridine (3ii), 2‘-deoxy-5-isopropyl-4‘-thiouridine (3iii), 5-cyclopropyl-2‘-deoxy-4‘-thiouridine (3iv), 2‘-deoxy-4‘-thio-5-vinyluridine (3viii), and 5-(2-chloroethyl)-2‘-deoxy-4‘-thiouridine (3xx) were found to be highly active against herpes simplex virus type-1 (HSV-1) and varicella zoster virus (VZV) in vitro with no significant cytotoxicity. The compound with the broadest spectrum of activity was 2‘-deoxy-5-ethyl-4‘-thiouridine (3i) which showed significant activity against HSV-1, HSV-2, and VZV.Keywords
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