Benzophenanthridine Alkaloids fromZanthoxylum nitidum (Roxb.) DC, and Their Analgesic and Anti-Inflammatory Activities
Authors:
- 22 September 2006
- journal article
- research article
- Published by Wiley in Chemistry & Biodiversity
- Vol. 3 (9) , 990-995
Abstract
Seven benzophenanthridine alkaloids, 1–7, were isolated from the roots of Zanthoxylum nitidum. Among them, two novel alkaloids, named (R)‐8‐[(R)‐1‐hydroxyethyl]dihydrochelerythrine (1) and 8‐methoxynorchelerythrine (2), were structurally identified as new compounds on the basis of the spectroscopic analysis. Bioactivity evaluation showed that nitidine (3), dihydrochelerythrine (4), oxyavicine (5), 8‐methoxychelerythrine (6), and 8‐hydroxydihydrochelerythrine (7) exhibit comparable analgesic and anti‐inflammatory effects as hydrocortisone.Keywords
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