Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Significance: An estimated 5 million people are at risk of infection by Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever. JUNV displays a glycoprotein spike complex on the surface of the viral envelope that is responsible for negotiating host-cell recognition and entry. Herein, we show that monoclonal antibodies that have gone through different germline selection pathways have converged to target the host-cell receptor-binding site on the JUNV glycoprotein spike. Immunofocusing of the antibody response to mimic natural host–receptor interactions reveals a key point of vulnerability on the JUNV surface.
Funding Information
  • European Commission (658363)
  • Medical Research Council (MR/J007897/1)
  • Medical Research Council (MR/K024426/1)
  • Medical Research Council (MR/N002091/1)
  • Swiss National Science Foundation (310030_149340/1)
  • Wellcome Trust (090532/Z/09/Z)
  • HHS | National Institutes of Health (1UM1AI100663)
  • HHS | National Institutes of Health (R15 AI119803)
  • Medical Research Council (MR/L009528/1)

This publication has 56 references indexed in Scilit: