Determine the Role of FSH Receptor Binding Inhibitor in Regulating Ovarian Follicles Development and Expression of FSHR and ERα in Mice

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Abstract
Mice of FRBI-1, FRBI-2, and FRBI-3 groups were intramuscularly injected with 20, 30, and 40mg/kg, respectively, for five consecutive days. Ovarian weights of three FRBI groups were reduced in comparison with FSH group. Ovarian cortex thicknesses (OCT) of the FRBI-3 group were less than that of the FSH group (Pα protein levels of FRBI group and serum concentrations of FSH and estradiol (E2) in the FRBI-treated mice were decreased when compared to CG and FSH group. In conclusion, FSH treatment could increase the numbers of SF and MF, enhance follicle development, reduce the numbers of SF and MF, and depress the follicular development of mice. Furthermore, FRBI declined the mRNA and protein levels of ERα and FSHR in the ovaries and dropped serum concentrations of FSH and E2 of mice.
Funding Information
  • State Key Research and Development Program in 13th Five-Year of China (2016 YFC0502601, 2017C-01, 41671041, 31460684)
  • Reproductive Biotechnology Innovation Team of Animals (2016 YFC0502601, 2017C-01, 41671041, 31460684)
  • Colleges and universities of Gansu Province (2016 YFC0502601, 2017C-01, 41671041, 31460684)
  • National Natural Science Foundation of the People’s Republic of China (2016 YFC0502601, 2017C-01, 41671041, 31460684)
  • National Natural Science Foundation of the People’s Republic of China (2016 YFC0502601, 2017C-01, 41671041, 31460684)

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