Optical behaviors of ZnO-porphyrin conjugates and their potential applications for cancer treatment
- 7 April 2008
- journal article
- Published by AIP Publishing in Applied Physics Letters
- Vol. 92 (14) , 143901
Abstract
ZnO nanoparticles were synthesized and conjugated to the porphyrin derivative, meso-tetra (o-amino phenyl) porphyrin (MTAP). Energy transfer from the ZnO nanoparticles to MTAP was investigated and the energy transfer rate was measured to be as high as 83%. Compared with MTAP and ZnO alone, ZnO-MTAP conjugates have low toxicity under dark conditions but high phototoxicity in the human ovarian carcinoma cell line NIH:OVCAR-3. The results indicate that ZnO-MTAP conjugates may be useful in photodynamic therapy for deep cancer treatment.Keywords
This publication has 22 references indexed in Scilit:
- Investigation of water-soluble x-ray luminescence nanoparticles for photodynamic activationApplied Physics Letters, 2008
- X-ray Excited Optical Luminescence Studies of ZnO and Eu-Doped ZnO NanostructuresThe Journal of Physical Chemistry C, 2007
- Nanoscale ZnO‐Enhanced Fluorescence Detection of Protein InteractionsAdvanced Materials, 2006
- Optical Properties of ZnO NanostructuresSmall, 2006
- Temperature and pressure dependences of the copper-related green emission in ZnO microrodsJournal of Applied Physics, 2006
- Photoluminescence and Electron Paramagnetic Resonance of ZnO Tetrapod StructuresAdvanced Functional Materials, 2004
- Photosensitizers in clinical PDTPhotodiagnosis and Photodynamic Therapy, 2004
- Sample Preparation and Photoluminescence of ZnO Particles Embedded in Thin Alkali Halide CrystalsJapanese Journal of Applied Physics, 1999
- Photophysics and photochemistry of quantized zinc oxide colloidsThe Journal of Physical Chemistry, 1992
- New trends in photobiologyJournal of Photochemistry and Photobiology B: Biology, 1989