Photonuclear Alchemy: Obtaining Medical Isotopes of Gold from Mercury Irradiated on Electron Accelerators
Authors:
- Andrey G. KazakovAKAndrey G. Kazakov
- Julia S. BabenyaJBJulia S. Babenya
- Taisya Y. EkatovaTETaisya Y. Ekatova
- Sergey S. BelyshevSBSergey S. Belyshev
- Vadim V. KhankinVKVadim V. Khankin
- Omar AlbaghdadiOAOmar Albaghdadi
- Alexander A. KuznetsovAKAlexander A. Kuznetsov
- Illarion I. DovhyiIDIllarion I. Dovhyi
- Nikolay A. BezhinNikolay A. Bezhin
- Ivan G. TananaevITIvan G. Tananaev
Open Access
Abstract
In our work, the photonuclear production of 198,199Au isotopes for nuclear medicine purposes was studied, and a method for their recovery from irradiated mercury was developed. The yields of the corresponding nuclear reactions were determined, and a comparison of various methods of obtaining gold radioisotopes was provided. New sorbents based on benzo-15-crown-5, which selectively binds gold, were studied, and the optimal conditions for Au recovery with a high degree of purification from mercury were found. It was established that, for the fast and quantitative recovery of Au isotopes, it was necessary to add at least 0.1 mg of the carrier. As a result, the developed method can be regularly used to obtain 198,199Au for the research of radiopharmaceuticals based on them.Keywords
Funding Information
- SSU (42-01-09/169/2021-7)
- state task (FNNN-2022-0004)
This publication has 31 references indexed in Scilit:
- Photonuclear reactions on mercury isotopes in the region of the giant-dipole-resonance energyPhysics of Atomic Nuclei, 2011
- Production of no-carrier-added 199Au for gold cluster-labelled antibodiesApplied Radiation and Isotopes, 1993
- N-(Hydroxymethyl)thioamide resin as stationary phase in ion-exchange chromatography for metal ion separationJournal of Chromatography A, 1991
- DISTRIBUTION COEFFICIENTS AND ION EXCHANGE BEHAVIOUR OF SOME CHLORIDE COMPLEX FORMING ELEMENTS WITH BIO RAD AG50W-XB CATION EXCHANGE RESIN IN MIXED NITRIC-HYDROCHLORIC ACID SOLUTIONSSolvent Extraction and Ion Exchange, 1989
- Antibodies labeled with 199Au: Potential of 199Au for radioimmunotherapyInternational Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1988
- Activation yield curves of photonuclear reactions for multielement photon activation analysisNuclear Instruments and Methods, 1978
- Production of carrier-free 199Au from irradiated platinum using 1-phenyl-3-methyl-4-trifluoroacetyl-pyrazolone-5 as an extractantThe International Journal of Applied Radiation and Isotopes, 1978
- A highly selective and sensitive method for identification of goldMicrochimica Acta, 1976
- Distribution coefficients for 53 elements in hydrochloric acid (1,2 M)-water-acetone medium on Dowex 50W-X12Journal of Chromatography A, 1975
- Rapid carrier free separation techniqueNuclear Instruments and Methods, 1961