A Placebo-Controlled, Double-Blind, Randomized Trial of Cyclosporine Therapy in Active Chronic Crohn's Disease
Authors:
- Leif FreundLFLeif Freund
- Sten Nørby RasmussenSRSten Nørby Rasmussen
- Karsten LauritsenKLKarsten Lauritsen
- Ove Schaffalitzky de MuckadellOMOve Schaffalitzky de Muckadell
- Noel WilliamsNWNoel Williams
- Allan S. MacDonaldAMAllan S. MacDonald
- Ronald TantonRTRonald Tanton
- Fernando MolinaFMFernando Molina
- Maria C. CampaniniMCMaria C. Campanini
- Paolo BianchiPBPaolo Bianchi
- Tullio RanziTRTullio Ranzi
- 28 September 1989
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 321 (13) , 845-850
Abstract
We randomly assigned 71 patients with active chronic Crohn's disease who were resistant to or intolerant of corticosteroids to treatment with oral cyclosporine (5 to 7.5 mg per kilogram of body weight per day) or placebo for three months. Disease activity was assessed on a clinical grading scale without knowledge of the treatment given.Keywords
This publication has 14 references indexed in Scilit:
- Cyclosporin-associated nephropathy in patients with autoimmune diseasesJournal of Molecular Medicine, 1988
- Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional TherapyCanadian Journal of Gastroenterology and Hepatology, 1988
- Combined steroid-cyclosporin treatment of chronic autoimmune diseasesJournal of Molecular Medicine, 1987
- Clinical Pharmacokinetics of CyclosporinClinical Pharmacokinetics, 1986
- Prognosis in Crohn's disease--based on results from a regional patient group from the county of Copenhagen.Gut, 1985
- Azathioprine has a very limited role in the treatment of Crohn's diseaseDigestive Diseases and Sciences, 1981
- Azathioprine and 6-mercaptopurine have a role in the treatment of Crohn's diseaseDigestive Diseases and Sciences, 1981
- Treatment of Crohn's Disease with 6-MercaptopurineNew England Journal of Medicine, 1980
- Development of a Crohn's Disease Activity IndexGastroenterology, 1976
- Tables of Critical Values for the Pratt Matched Pair Signed Rank StatisticJournal of the American Statistical Association, 1974