Reduced bone density in individuals with severe hemophilia B

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Abstract
The reduced bone density in individuals with severe hemophilia A (decreased coagulation factor VIII level) and combined factor V and VIII deficiency have been reported. In the current case-control study we tried to address bone mineral density in individuals with severe hemophilia B (decreased coagulation factor IX). In our case-control study, we recruited bone density and biochemical indexes in 14 individuals with severe hemophilia B and compared obtained results with 14 age- and sex-matched control group results. Our results showed individuals with severe hemophilia B had reduced bone density in lumbar (-0.34 +/- 0.97) and femur (-0.82 +/- 1.37) regions, compared to the control group (0.84 +/- 0.53 and 1.02 +/- 1.04 respectively; P-value = 0.000 and 0.000). The foremost complication of coagulation disorders are various types of excessive bleedings. The current study revealed severe hemophiliac B patients are prone to reduced bone density similar to severe hemophiliac A patients.

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