The chondrogenesis of rib perichondrial grafts for repair of full thickness articular cartilage defects in a rabbit model: A one year postoperative assessment

Authors:
  • RCRichard D. Coutts
    Richard D. Coutts
  • FHFrederick L. Harwood
    Frederick L. Harwood
  • KIKenneth K. Ishizue
    Kenneth K. Ishizue
  • JKJeffrey B. Kleiner
    Jeffrey B. Kleiner
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Abstract
The purpose of this study was to investigate the results or rib perichondrial grafting after the creation of a full thickness articular cartilage defect. In a rabbit model, rib perichondrium was used to repair defects created in the femoral condyle. The formation of repair tissue (neocartilage) and its chondrogenesis into a tissue resembling articular cartilage was found over time. The gross, histological and biochemical characteristics of the neocartilage were evaluated at intervals of 6, 12, 18, 26 and 52 weeks post transplant, and compared to normal articular cartilage. The neocartilage was characterized by the early formation of relatively large amounts of glycosaminoglycans. A steady increase in the proportion of type II collagen over the time periods was also observed. Improved attachment of the neocartilage to host tissues was seen over the period of 6 to 52 weeks. Successful grafts were seen to proliferate to fill the articular defect and to undergo a chondrogenesis over a post transplant time period of one year.

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