Supplementary Table S2 shows regression coefficients that denote the difference in average DNA methylation level, as derived from the mean methylation ratios across all estimated CpG sites in the F2RL3 gene, and their associated 95%CI relative to the reference group. Multivariable models included adjustment for age, sex (not for stratified models), phase of blood sampling, education level, ethnicity, and smoking (CSI - cumulative smoking index). A probability of exposure of 0% was categorized as unexposed; “Possibly exposed” if the probability of exposure was >0% and <25% and; “Exposed” to a given agent if the probability of exposure was ≥25%.