Review: Microglia in protein aggregation disorders: friend or foe?
- 22 January 2013
- journal article
- review article
- Published by Wiley in Neuropathology and Applied Neurobiology
- Vol. 39 (1) , 45-50
Abstract
Microglia cells have been implicated, to some extent, in the pathogenesis of all of the common neurodegenerative disorders involving protein aggregation such as Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis. However, the precise role they play in the development of the pathologies remains unclear and it seems that they contribute to the pathological process in different ways depending on the specific disorder. A better understanding of their varied roles is essential if they are to be the target for novel therapeutic strategies.Keywords
This publication has 52 references indexed in Scilit:
- Physiology of MicrogliaPhysiological Reviews, 2011
- Microglia in ALS: The Good, The Bad, and The RestingJournal of Neuroimmune Pharmacology, 2009
- Heterogeneity of Microglial Activation in the Innate Immune Response in the BrainJournal of Neuroimmune Pharmacology, 2009
- Expression of insulin‐like growth factor‐II and leukemia inhibitory factor antibody immunostaining on the ionized calcium‐binding adaptor molecule 1‐positive microglias in the spinal cord of amyotrophic lateral sclerosis patientsNeuropathology, 2007
- Pathological relationships between microglial cell activity and tau and amyloid β protein in patients with Alzheimer's diseaseNeuroscience Letters, 2002
- Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of MicrogliaJournal of Neuroscience, 2000
- Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer's diseaseNeuroscience Letters, 2000
- Distribution of interleukin‐1‐immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer’s diseaseNeuropathology and Applied Neurobiology, 1998
- Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosisNeuropathology and Applied Neurobiology, 1990
- Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.Proceedings of the National Academy of Sciences, 1989