Tissue self-organization based on collective cell migration by contact activation of locomotion and chemotaxis

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Abstract
Significance: Migration of cells as a group is pivotal to the making of various tissues in developing embryos; however, their complexity hinders one from identifying the exact rules. We exploited relatively simple and conditional multicellularity of the social amoebaDictyosteliumto analyze tissue patterning from bottom up by identifying the navigation rules at the individual cell level. We uncovered a guidance mechanism directed by cell–cell contact which gives rise to collective migration and competes with diffusive attractant molecules. Competition of the two directional cues forms the basis of how cells position themselves in the multicellular aggregate according to cell type. A similar scheme of collective migration and sorting may underlie patterning of other developing tissues as well as cancer invasion.
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Funding Information
  • Ministry of Education, Culture, Sports, Science and Technology (JP18H04759)
  • Ministry of Education, Culture, Sports, Science and Technology (JP16H01442)
  • MEXT | Japan Society for the Promotion of Science (JP17H0812)
  • MEXT | Japan Society for the Promotion of Science (JP15KT0076)
  • Ministry of Education, Culture, Sports, Science and Technology (JP17H05992)
  • MEXT | Japan Society for the Promotion of Science (25710022)
  • MEXT | Japan Society for the Promotion of Science (25103008)
  • MEXT | Japan Society for the Promotion of Science (JP16K18537)
  • MEXT | Japan Society for the Promotion of Science (JP17J08690)

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