Heterogenized (PNNP)Ru Complex Catalyst on Merrifield Resin for Hydrogenation of Unactivated Amides

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Abstract
Hydrogenation of amides with selective C–N bond cleavage over C–O scission remains challenging, especially under heterogenized molecular catalysis. Herein, we report the immobilization of a robust ruthenium complex on the surface of Merrifield resin (RuPCY2@MR) as a highly effective and selective heterogenized organometallic catalyst for the C–N bond cleavage of amides. Characterization of this complex was performed employing different techniques, including ICP-AES, IR, XRF, TGA, XPS, 31P CP/MAS NMR, and SEM. This heterogenized catalyst enables the hydrogenation of different unactivated aromatic and aliphatic amides with excellent selectivity toward C–N scission in up to 99% yield with low catalyst loadings (1 mol %). The heterogeneity of this catalyst was proven by a hot filtration test, and catalyst recycling was performed in up to three cycles.
Funding Information
  • Deutsche Forschungsgemeinschaft (IRTG 2678 (GRK 2678-437785492))
  • Japan Society for the Promotion of Science (22K21346)
  • Japan Society for the Promotion of Science (23H04904)
  • Japan Society for the Promotion of Science (23H05404)
  • Japan Society for the Promotion of Science (24H01071)
  • Japan Society for the Promotion of Science (25K18029)
  • Core Research for Evolutional Science and Technology (JPMJCR22L2)

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