Frequency and Quantitative Levels ofTγ Chain (Hb F Sardinia) in the Fetal Hemoglobin of Newborn and Fetuses
Authors:
- L. F. BerniniLBL. F. Bernini
- P. C. GiordanoPGP. C. Giordano
- D. A. F. van LithDLD. A. F. van Lith
- 1 January 1980
- journal article
- Published by Taylor & Francis in Hemoglobin
- Vol. 4 (3-4) , 469-482
Abstract
The fetal hemoglobin of 137 Dutch newborn has been examined by peptide mapping after digestion with trypsin, in order to detect the Tγ chain (γ chain bearing a replacement lle→Thr at position 75) and to assess its quantity relative to the total γ chains. Forty-two (31%) individuals were carriers of this variant, with an average amount of Tγ chain equal to 18.89% ± 4.12 (1 SD). Three babies had Tγ levels higher than 30%, outside, therefore, the upper limit of the distribution. If we consider these three children homozygous carriers and assume that the remaining thirty-nine are heterozygotes, the gene frequency of Tγ in this population is 0.16 and the observed frequencies of the three phenotypes (Tγ-/-, Tγ+/- and Tγ+/+) agree closely with the expected ones.Keywords
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