031 Collagenase Injection Into the Peyronie’s Disease-Like Plaque in A Rat Model Reduces not Just Plaque Size, but Selectively Myofibroblast Content, and is Associated With Increased Apoptosis, Replicating the Effects of A PDE5 Inhibitor Given Separately, but not in Combination

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Abstract
Clinical trials demonstrate that clostridium histolyticum collagenase (CHC) intraplaque injection (Xiaflex) is an effective therapy for correcting the curvature associated with Peyronie’s disease (PD). Since the myofibroblast is the cell within the plaque that is responsible for plaque formation, and its persistence may lead to recurrence, and since PDE5 inhibitors (PDE5i) reduce myofibroblasts via apoptosis, we tested the effect of CHC alone or combined with a PDE5i on myofibroblast content and turnover in a rat model of PD.