Assessment of Disease Activity in Ulcerative Colitis Using Indium-111-Labelled Leukocyte Faecal Excretion

Authors:
  • SSS. H. Saverymuttu
    S. H. Saverymuttu
  • APA. M. Peters
    A. M. Peters
  • HHH. J. F. Hodgson
    H. J. F. Hodgson
  • VCV. S. Chadwick
    V. S. Chadwick
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Abstract
A new method of assessing disease activity in ulcerative colitis has been developed utilizing 111In-labeled granulocytes. Fecal 111In excretion after i.v. administration of labeled granulocytes ranged from 1.1-45% of the injected dose in patients with ulcerative colitis, showing significant differences between mild, moderate and severely active groups. There was a significant correlation between fecal 111In excretion and a clinical index based on the Crohn''s disease activity index (r = 0.79, P < 0.01) and the erythrocyte sedimentation rate (r = 0.73, P < 0.001). Quantitative fecal 111In-labeled granulocyte excretion is an objective and specific method of assessing disease activity in ulcerative colitis.

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