The intraportal injection model: A practical animal model for hepatic metastases and tumor cell dissemination in human colon cancer
Authors:
- Andreas ThalheimerATAndreas Thalheimer
- Christoph OttoCOChristoph Otto
- Marco BueterMBMarco Bueter
- Bertram IllertBIBertram Illert
- Stefan GattenlohnerSGStefan Gattenlohner
- Martin GasserMGMartin Gasser
- Detlef MeyerDMDetlef Meyer
- Martin FeinMFMartin Fein
- Christoph T GermerCGChristoph T Germer
- Ana M Waaga-GasserAWAna M Waaga-Gasser
Open Access
- 24 January 2009
- journal article
- Published by Springer Nature in BMC Cancer
- Vol. 9 (1) , 29
Abstract
The development of new therapeutic strategies for treatment of metastasized colorectal carcinoma requires biologically relevant and adequate animal models that generate both reproducible metastasis and the dissemination of tumor cells in the form of so-called minimal residual disease (MRD), an expression of the systemic character of neoplastic disease.Keywords
This publication has 24 references indexed in Scilit:
- Systemic Spread Is an Early Step in Breast CancerCancer Cell, 2008
- Orthotopic Microinjection of Human Colon Cancer Cells in Nude Mice Induces Tumor Foci in All Clinically Relevant Metastatic SitesThe American Journal of Pathology, 2007
- In vivo Color-Coded Imaging of the Interaction of Colon Cancer Cells and Splenocytes in the Formation of Liver MetastasesCancer Research, 2006
- Cancer Statistics, 2006CA: A Cancer Journal for Clinicians, 2006
- Disseminated tumor cells in the blood of patients with gastric cancer are an independent predictive marker of poor prognosisScandinavian Journal of Gastroenterology, 2005
- Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal CancerNew England Journal of Medicine, 2004
- Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude miceEuropean Journal of Cancer, 2004
- Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal CancerNew England Journal of Medicine, 2004
- Xenograft Models for Liver Metastasis: Relationship between Tumor Morphology and Adenovirus Vector TransductionMolecular Therapy, 2004
- Optimization of a metastasizing human gastric cancer model in nude miceMicrosurgery, 2003