An Improved Method for the Synthesis of N-Phenoxyacetylribonucleosides
Authors:
- 1 July 1995
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 25 (13) , 1997-2003
Abstract
N-phenoxyacetylribonucleosides were prepared efficiently from the reaction of ribonucleosides with phenoxyacetylchloride and 1,2,4-triazole(for adenosine and cytidine) or 1-hydroxybenzotriazole (for guanosine).Keywords
This publication has 8 references indexed in Scilit:
- Ribozymes: Killing the MessengerScience, 1993
- Ribozymes as Potential Anti-HIV-1 Therapeutic AgentsScience, 1990
- Solid phase synthesis of the 5′-half of the initiator t-RNA fromB.subtilisNucleic Acids Research, 1989
- Prevention of chain cleavage in the chemical synthesis of 2′-silylated oligoribonucleotidesNucleic Acids Research, 1989
- The use of labile base protecting groups in oligoribonucleotide synthesisTetrahedron Letters, 1989
- N-Phenoxyacetylated guanosine and adenosine phosphoramidites in the solid phase synthesis of oligoribonucleotides: Synthesis of a ribozyme sequenceTetrahedron Letters, 1988
- The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groupsNucleic Acids Research, 1987
- Transient protection: efficient one-flask syntheses of protected deoxynucleosidesJournal of the American Chemical Society, 1982