Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles
- 22 April 2019
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Nanoscale
- Vol. 11 (19) , 9756-9759
Abstract
Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic PEG unit and a hydrophobic stearyl chain. The epipodophyllotoxin-containing amphiphiles were assembled into the corresponding micelles which were evaluated in vivo for their tumor targeting properties.Keywords
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