Reduced left rostral anterior cingulate surface area in unmedicated pediatric obsessive-compulsive disorder

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Abstract
BackgroundObsessive-compulsive disorder (OCD) is a severe psychiatric disorder typically emerging in childhood or adolescence. OCD models link the disorder to cortico-striato-thalamo-cortical pathway imbalances, favoring habitual over goal-directed behavior. Neuroanatomical alterations in unmedicated pediatric OCD studies have reported cortical thinning in the superior and inferior parietal cortices, lower grey matter density and lower white matter volume in the anterior cingulate cortex (ACC), and larger thalamic volume.