The Effects of Cimetidine on the Oxidative Metabolism of Estradiol
Authors:
- Jon J. MichnoviczJMJon J. Michnovicz
- 3 August 1989
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 321 (5) , 269-274
Abstract
Cimetidine, a histamine H2–receptor antagonist widely used to treat peptic ulceration, is known to cause gynecomastia and sexual dysfunction in some men. Since cimetidine inhibits the cytochrome P-450–dependent biotransformation of numerous drugs, we investigated the possibility that it might also inhibit the cytochrome P-450–dependent metabolism of estradiol.Keywords
This publication has 44 references indexed in Scilit:
- Inhibitory effects of ketoconazole and miconazole on cytochrome P-450-mediated oxidative metabolism of testosterone and xenobiotics in mouse hepatic microsomes - Comparative study with cimetidine.Journal of Pharmacobio-Dynamics, 1988
- Increased 2-Hydroxylation of Estradiol as a Possible Mechanism for the Anti-Estrogenic Effect of Cigarette SmokingNew England Journal of Medicine, 1986
- The effects of H2-receptor antagonists and imidazole on testosterone hydroxylations in mouse liver microsomes.Chemical and Pharmaceutical Bulletin, 1984
- Effect of cimetidine on the pharmacokinetics and pharmacodynamics of quinidineThe American Journal of Cardiology, 1983
- Cimetidine-Induced Impotence and Breast Changes in Patients with Gastric Hypersecretory StatesNew England Journal of Medicine, 1983
- Estrogen Excretion Patterns and Plasma Levels in Vegetarian and Omnivorous WomenNew England Journal of Medicine, 1982
- Male sexual dysfunction during treatment with cimetidine.BMJ, 1979
- Gynaecomastia associated with cimetidine.Gut, 1979
- Gas chromatographic and mass spectrometric studies on oestrogens in bile—2. Men and non-pregnant womenThe Journal of Steroid Biochemistry and Molecular Biology, 1978
- High-Pressure Liquid Chromatographic Analysis of Cimetidine, a Histamine H2-Heceptor Antagonist, in Blood and UrineJournal of Pharmaceutical Sciences, 1977