Suppression of the mixed lymphocyte reaction in man by a soluble T-cell factor. Specificity of the factor for both responder and stimulator.
Authors:
- E G EnglemanEEE G Engleman
- A J McMichaelAMA J McMichael
- H O McDevittHMH O McDevitt
Open Access
- 1 April 1978
- journal article
- research article
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 147 (4) , 1037-1043
Abstract
J.H., an HLA-Dw2 homozygous multiparous woman, fails to respond to her husband, W.H. (HLA Dw1,-) in the unidirectional mixed lymphocyte reaction. T cells from J.H. were previously shown to suppress the responses of Dw2-positive cells but not Dw2-negative cells to W.H. We now report that a soluble factor released into the supernate of the mixed lymphocyte reaction by J.H. T cells, mediates this suppression. Like the cell from which it is derived, the factor is highly specific for HLA Dw2 in the responder cell and partially specific for the stimulatory alloantigen.Keywords
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