Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy
Authors:
Open Access
- 5 November 2021
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Network Open
- Vol. 4 (11) , e2132376
Abstract
Endovascular thrombectomy (EVT) improves functional outcomes in patients with acute ischemic stroke caused by large-vessel occlusions (LVO),1 partly by reducing infarct volumes.2-4 Follow-up or final imaging infarct volume (FIV), measured 24 to 48 hours post stroke, is associated with functional outcomes at 90 days assessed using the modified Rankin Scale (mRS) in patients with stroke due to LVO.5-7 However, there is only a moderate correlation of FIV to clinical outcomes,8,9 with FIV only explaining an estimated 12% of the variance in EVT treatment benefit using mediation analyses.10 Similarly, infarct volume was a modest predictor of 3-month mRS score and a poor predictor of health-related quality-of-life in a prospective cohort.11 Some patients have discrepancies between FIV and functional outcome: patients with small FIV can fare poorly while others with large FIV can fare well.Keywords
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