A Sn(iv) porphyrin with mitochondria targeting properties for enhanced photodynamic activity against MCF-7 cells
- 22 February 2022
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in New Journal of Chemistry
- Vol. 46 (11) , 5288-5295
Abstract
A Sn(iv) porphyrin with a mitochondria targeting triphenylphosphonium moiety has a highΦΔvalue (ca.0.72) and does not aggregate in aqueous solution. The dye exhibits favorable photodynamic activity against MCF-7 cells with an IC50value of 2.9 μM.Keywords
Funding Information
- National Research Foundation (119259, 62062)
- Council for Scientific and Industrial Research, South Africa
This publication has 45 references indexed in Scilit:
- Synthesis and biological evaluation of pyrazolo–triazole hybrids as cytotoxic and apoptosis inducing agentsOrganic & Biomolecular Chemistry, 2015
- Axial ligand modified high valent tin(iv) porphyrins: synthesis, structure, photophysical studies and photodynamic antimicrobial activities on Candida albicansRSC Advances, 2015
- Synthesis of tetraglucosyl- and tetrapolyamine–tetrabenzoporphyrin conjugates for an application in PDTBioorganic & Medicinal Chemistry, 2009
- Effect of zinc insertion and hydrophobicity on the membrane interactions and PDT activity of porphyrin photosensitizersPhotochemical & Photobiological Sciences, 2008
- Pharmacotherapy of Age-Related Macular Degeneration2006
- Highly cytotoxic iron(ii) complexes with pentadentate pyridyl ligands as a new class of anti-tumor agentsChemical Communications, 2005
- Methylviologen-pendant iron porphyrins as models of a reduction enzyme: six-electron reduction of nitrobenzene to anilineElectronic supplementary information (ESI) available: time-courses of reduction, UV-VIS spectral changes, cyclic voltammograms, EPR spectra, conversion and yield percentages for the reduction of p-nitroanisole. See http://www.rsc.org/suppdata/dt/b2/b211125j/Dalton Transactions, 2003
- Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1Advanced Drug Delivery Reviews, 2001
- Magnetic circular dichroism of aromatic moleculesTetrahedron, 1984
- On the preparation of metalloporphyrinsJournal of Inorganic and Nuclear Chemistry, 1970