Frequent Loss of Heterozygosity at the 19p13.3 Locus Without LKB1/STK11 Mutations in Human Carcinoma Metastases to the Brain
- 1 September 2000
- journal article
- Published by Springer Nature in Journal of Neuro-Oncology
- Vol. 49 (3) , 187-195
Abstract
Inactivating germline mutations of the novel putative tumor-suppressor gene LKB1/STK11at 19p13.3 have been shown to cause Peutz-Jeghers syndrome (PJS), an autosomal dominantly inherited disease...Keywords
This publication has 36 references indexed in Scilit:
- Novel mutations in theLKB1/STK11 gene in Dutch Peutz-Jeghers familiesHuman Mutation, 1999
- Somatic Mutations in the Peutz-Jegners (LKB1/STKII) Gene in Sporadic Malignant MelanomasJournal of Investigative Dermatology, 1999
- Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanomaOncogene, 1999
- Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancerHuman Molecular Genetics, 1999
- Increased Risk for Cancer in Patients with the Peutz-Jeghers SyndromeAnnals of Internal Medicine, 1998
- PTEN gene mutations are seen in high-grade but not in low-grade gliomas.1997
- Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p.1997
- A comprehensive genetic map of the human genome based on 5,264 microsatellitesNature, 1996
- Cancer and the Peutz-Jeghers syndrome.Gut, 1989
- Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and DigitsNew England Journal of Medicine, 1949