BLOOMS SYNDROME .4. SISTER-CHROMATID EXCHANGES IN LYMPHOCYTES
Authors:
- J GermanJGJ German
- S SchonbergSSS Schonberg
- E LouieELE Louie
- R S ChagantiRCR S Chaganti
- 1 January 1977
- journal article
- research article
- Vol. 29 (3) , 248-255
Abstract
An abnormally great amount of exchange between both sister and nonsister-but-homologous chromatids is a highly characteristic feature of cultured blood lymphocytes from individuals with Bloom''s syndrome. However, a population of lymphocytes which exhibit a normal amount of exchange can be detected in the blood of some individuals with this syndrome. This coexistence of cells with a greatly increased number of sister-chromatid exchanges and others with a normal number results in a phenotypic dimorphism, in apparent contradiction to the autosomal recessive mode of inheritance of the syndrome.Keywords
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