Two Catalytic Protocols for the Synthesis of CF2‐Containing Quinazolinones via Domino Reaction
Authors:
- 11 July 2024
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 366 (14) , 3181-3187
Abstract
Copper‐catalyzed and visible‐light catalytic difluoroalkylation reactions of N‐cyanamide alkenes have been developed. Various α‐bromodifluoromethyl substituted esters, amides and heterocycles were employed as the CF2 source. Both protocols are characterized by medium to high yields, good functional group compatibility, and applicable to gram‐scale synthesis. Comparable studies of copper catalysis and photoredox catalysis demonstrate minimal differences between the two protocols. Preliminary mechanism suggest that both transformations involve tandem radical cyclization process.Keywords
Funding Information
- National Natural Science Foundation of China (22271069, 21871067)
- Shenzhen Graduate School, Peking University (GXWD20231130100539001)
- Basic and Applied Basic Research Foundation of Guangdong Province (2023A1515012457, 2021A1515010190)
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