First Stereoselective Synthesis of 2-Deoxy-α-d-ribosyl-1-phosphate: Novel Application of Crystallization-Induced Asymmetric Transformation
- 18 June 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (15) , 5419-5421
Abstract
A first stereoselective synthesis of bis(cyclohexylamine) 2-deoxy-α-d-ribosyl-1-phosphate has been achieved. The synthesis features a key crystallization-induced asymmetric transformation (AT) to generate a desired α-anomer in 99% yield at a 98.8:1.2 ratio of α/β.Keywords
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