Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced in vivo homing capacity compared to plerixafor alone
Open Access
- 29 December 2016
- journal article
- Published by Ferrata Storti Foundation (Haematologica) in Haematologica
- Vol. 102 (4) , e120-e124
Abstract
For decades, bone marrow (BM) has been the preferred source of hematopoietic stem and progenitor cells (HSPCs) for transplants following myeloablative conditioning. At present, mobilized peripheral blood stem cells are commonly used for transplantation, particularly in the autologous setting.[1][1Keywords
This publication has 14 references indexed in Scilit:
- Mild Heat Treatment Primes Human CD34+ Cord Blood Cells for Migration Toward SDF-1α and Enhances Engraftment in an NSG Mouse ModelStem Cells, 2015
- Hematopoietic Stem Cell Mobilization for Gene Therapy: Superior Mobilization by the Combination of Granulocyte–Colony Stimulating Factor Plus Plerixafor in Patients with β-Thalassemia MajorHuman Gene Therapy, 2013
- Transcriptome Analysis Identifies Regulators of Hematopoietic Stem and Progenitor CellsStem Cell Reports, 2013
- Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage EngraftmentScience, 2011
- Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signaturesBlood, 2009
- Human Progenitor Cells Rapidly Mobilized by AMD3100 Repopulate NOD/SCID Mice with Increased Frequency in Comparison to Cells from the Same Donor Mobilized by Granulocyte Colony Stimulating FactorTransplantation and Cellular Therapy, 2007
- AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primatesBlood, 2006
- Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonistJournal of Experimental Medicine, 2005
- The bicyclam AMD3100 storyNature Reviews Drug Discovery, 2003
- Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesisBlood, 2003