Halogenated and Nonhalogenated Metabolites from the Marine-Alga-Endophytic Fungus Trichoderma asperellum cf44-2

Authors:
Open Access
Publisher website
Google Scholar
Abstract
One new bisabolane sesquiterpene, bisabolan-1,10,11-triol (1), one new norbisabolane sesquiterpene, 12-nor-11-acetoxybisabolen-3,6,7-triol (2), two new naturally occurring monoterpenes, (7S)- and (7R)-1-hydroxy-3-p-menthen-9-oic acids (3 and 4), one new naturally occurring trichodenone, dechlorotrichodenone C (5), one new chlorine-containing trichodenone, 3-hydroxytrichodenone C (6), one new diketopiperazine, methylcordysinin A (7), and one new naturally occurring oxazole derivative, 4-oxazolepropanoic acid (8), were isolated from the culture of a marine brown alga-endophytic strain (cf44-2) of Trichoderma asperellum. Their structures and relative configurations were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of 3–6 were assigned by analysis of the ECD spectra aided by quantum chemical computations. Compounds 1, 2, 5, and 6 showed growth inhibition of some marine phytoplankton species and pathogenic bacteria.
Funding Information
  • National Natural Science Foundation of China (31670355)
  • Natural Science Foundation for Distinguished Young Scholars of Shandong Province (JQ201712)
  • Open Fund of Key Laboratory of Experimental Marine Biology, CAS (KF2017NO4)
  • Youth Innovation Promotion Association of CAS (2013138)
  • Self-Fund from Yantai Institute of Coastal Zone Research, CAS (Y755031012)

This publication has 19 references indexed in Scilit: