Triflic Acid‐Mediated Synthesis of 2‐Sulfonamido Substituted 4 H ‐Chromenes From para ‐Quinone Methides and Their Antiplasmodial Activity

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Abstract
An expedited synthesis of 2‐sulfonamido‐substituted 4 H ‐chromene derivatives via reaction between para ‐quinone methides and ynamides in the presence of triflic acid at room temperature is described. Most of the synthesized compounds displayed potent antiplasmodial activity against both the chloroquine‐sensitive and ‐resistant strains of Plasmodium falciparum with a good selectivity index.
Funding Information
  • Council of Scientific and Industrial Research, India (MLP‐2032)

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